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The relationship between dietary ω‐3 and ω‐6 intake and colorectal cancer (LB350)
Author(s) -
Kunihiro Andrew,
Wang Long,
Reiboldt Wendy,
Devine Wendy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb350
Subject(s) - medicine , colorectal cancer , logistic regression , national health and nutrition examination survey , cancer , cohort , odds ratio , demography , environmental health , population , sociology
The purpose of this study was to investigate any relationship between dietary ω‐3 and ω‐6 fatty acid intake and the prevalence of colorectal cancer (CRC) and systematic inflammation, as measured by the Glasgow Prognostic Score (GPS) in a cohort of American men and women from various ethnic backgrounds. The CRC is the fourth leading cause of cancer‐related deaths and the second most expensive in the United States. Low screening compliance predisposes a large portion of those at‐risk to poor outcomes. Identification of screening markers and primary interventions is therefore of utmost importance. The GPS is a validated predictor of cancer survivability that reflects systemic inflammation. Dietary ω‐3 and ω‐6 fatty acid intake has been shown to modulate systemic inflammation. Men and women of various ethnic backgrounds from the National Health and Nutrition Examination Survey, 1999‐2010, were eligible for inclusion. Self‐reported dietary ω‐3 and ω‐6 intakes were used to determine the cross‐sectional relationship with CRC, using multiple logistic regression, or the GPS, using the chi‐square statistic. For those 20 to less than 50 years old (n=16,163) the relationship with CRC (n=11) for ω‐3 intake was negative (OR:0.604, p=0.022, 95% CI: 0.392, 0.931); ω‐6 intake was positive, (OR:1.074, p=0.023, 95% CI: 1.010, 1.143); and the ω‐3:ω‐6 ratio was negative, (OR: 0.016, p=0.027, 95% CI:<0.001, 0.616); after multivariate adjustment. The GPS was also found to be significantly related to both ω‐3, χ2 (6) = 36.97 (p < .0001), and ω‐6 fatty acid intake, χ2 (6) = 35.94, (p <.0001), for those 50 years and older (n=15,178) and to ω‐3, χ2 (6) = 21.72,(p = .0014) and ω‐6, χ2 (6) = 41.14, (p <.0001) for those younger than 50. These findings support previous findings of a relationship between ω‐3 and ω‐6 fatty acids and cancer, although their effects may differ based on age, suggesting that intake levels of these fatty acids might be of more value as an indicator of risk for CRC in people younger than 50. In addition, this appears to be the first report of a relationship between ω‐3 and ω‐6 fatty acids and the GPS.