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Lipopolysaccharide Binding Protein is Associated with Diet Composition and Metabolic Markers in Obese Adults (LB340)
Author(s) -
Clifford Kerry,
Piazza Bryana,
Keshavarzian Ali,
Tangney Christy,
Coltman Anne,
Hartney Chris,
Shawron Krista,
Raeisi Shohreh,
Forsyth Christopher,
Hutkins Robert,
Krumbeck Janina,
Rasmussen Heather
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb340
Subject(s) - waist , medicine , systemic inflammation , blood pressure , lipopolysaccharide binding protein , metabolic syndrome , endocrinology , obesity , saturated fat , inflammation , gastroenterology , acute phase protein , cholesterol
Intestinal microbiota is modulated by dietary intake and can have a profound impact on systemic health through initiation of systemic inflammation [via bacterial products like lipopolysaccharide (endotoxin)] and promotion of inflammation associated disorders like metabolic syndrome. Whether specific dietary components are related to markers of gut and systemic health, in particular, lipopolysaccharide binding protein or LBP (low level is a measure of systemic endotoxin exposure) is currently unknown. Bloods acquired from 32 healthy, obese (BMI, mean ±SD; 36.6 ± 6.1 kg/m 2 ) subjects were analyzed for metabolic markers and LBP concentrations; three‐day food records were also completed. Median (IQR) age was 51 (40, 55), 56% were African American, 78 % were female, and 37% had metabolic syndrome. Subjects had a mean waist circumference of 116.5 ± 13.4 cm and systolic/diastolic blood pressures of 132.3 ± 15.6/78.8 ± 13.3 mm Hg. Median (IQR) LBP was 10.3 μg/ml (6.3, 23.3). Mean ± SD daily energy intake was 2,112 ± 636 kcal, saturated fat (g) 29.8 ± 97.3 (12.8 ± 3.3% of energy), mean fiber/1000 kcal (g) 8.4± 3.0, and median sugar intake (IQR) 78g (49,100). There was an inverse correlation between LBP and the following parameters: systolic blood pressure (r=‐0.41, p=0.04), saturated fat (g) (r=‐0.49, p=0.01), and calcium (r=‐0.41, p=0.03). The inverse relationships observed between LBP and both saturated fat and calcium indicates that foods high in these dietary components, such as high fat diary, may impact systemic inflammation through a gut‐mediated mechanism. Grant Funding Source : USDA NIFA AFRI