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Effect of bitter melon on blood glucose and lipid levels in streptozotocin‐induced diabetic rats (LB335)
Author(s) -
Kim MyungWha,
Han Hye Kyoung,
Hwang EunJung
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb335
Subject(s) - streptozotocin , malondialdehyde , medicine , diabetes mellitus , endocrinology , tail vein , plasma glucose , body weight , lipid profile , oxidative stress , biology , microbiology and biotechnology , in vivo
This study was designed to examine the effects of bitter melon (BM) on the plasma blood glucose and lipid levels in diabetic rats. Diabetes mellitus was induced in male Sprague‐Dawley rats through an injection of streptozotocin (STZ) dissolved in a 0.01 M citrate buffer into the tail vein at a dose of 45 mg/kg of body weight. Sprague‐Dawley rats were then fed for four weeks, with the experimental groups receiving a modified diet containing 5% or 10% powder derived from BM. The experimental groups were divided into 4 groups, consisting of the normal control group, STZ‐control group and diabetic fed with BM 5% & 10% treated groups. The blood glucose was significantly decreased in the 5% & 10% BM of the diabetic group. Malondialdehyde (MDA) level in liver showed not changes in diabetic experimental groups. These results indicate that the supplementation of BM may have a favorable influence on reducing the blood glucose level in STZ‐induced diabetic rats.Grant Funding Source : Supported by 2013 Research Fund of Duksung Women’s University