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Effects of Calorie Restriction on Total and Heligmosomoides bakeri ‐specific IgG1 in Mice of Differing Immune Phenotypes (LB307)
Author(s) -
Jablanovic Jelena,
Lang Samantha,
Manibusan Pierre,
Kristan Deborah
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb307
Subject(s) - immune system , antibody , biology , pathogen , immunology , specific pathogen free , immunoglobulin g , antibody response , microbiology and biotechnology , virus
Calorie restriction (CR) is currently being investigated in humans for therapeutic effects on longevity and age‐associated diseases. However, some preliminary animal studies have shown that CR can adversely affect the immune system in the presence of infection; therefore the risk of CR needs to be further evaluated. In this study we subjected 2 immunologically different strains of laboratory mice (C57BL/6, SJL) to CR, and then infected them with intestinal nematode Heligmosomoides bakeri . We then measured a non‐specific immunoglobulin response (total IgG1) and a pathogen‐specific immunoglobulin response ( H. bakeri ‐specific IgG1). Overall, our study showed that C57 had a more robust total IgG1 response, but H. bakeri ‐specific IgG1 was similar in both strains. CR had an attenuating effect on total IgG1 in both C57 and SJL mice, but CR had no effect on the H. bakeri ‐specific IgG1 response in either strain. Taken together, our study showed that CR can attenuate a non‐specific immunoglobulin response and have no effect on pathogen‐specific response. However, we caution that effects of CR on pathogen‐specific response should further be investigated during longer or repeated infections. Grant Funding Source : NIH 5SC3GM084806