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Assessment of factors related to carbohydrate intolerance III: Fasting HOMA (LB300)
Author(s) -
Dalton R,
Levers K,
Galvan E,
Coletta A,
Jung Y,
O'Connor A,
Goodenough C,
Simbo S,
Seesselberg C,
Bonin B,
Koozehchian M,
Sanchez B,
Barringer N,
Rasmussen C,
Greenwood M,
Kreider R
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb300
Subject(s) - waist , insulin resistance , medicine , endocrinology , homeostatic model assessment , insulin , fasting glucose , obesity
The fasting homeostatic model assessment (HOMA) is a gold standard in assessing insulin resistance. However, the test is costly and time consuming. This study examined whether responses to a carbohydrate intolerance survey (CI) correlate to HOMA, an OGTT, body composition and/or markers of health. 108 women (31.6±13 yrs, 34.7±7% body fat, 25.3±4 kg/m 2 ) donated fasting blood samples, completed a CI inventory, had body composition and health measures determined, and underwent a 75g, 2‐hr OGTT. Pearson product correlations were performed to determine which factors correlated with HOMA. Results revealed significant correlations (p<0.05) in HOMA (1.51±1.1) to G 120 (r=0.37), glucose AUC (r=0.30), glucose AUMC (r=0.32), C max (r=0.24), fasting insulin (r=0.99), G/I ratio (r=‐0.49), height (r=‐0.27), waist circumference (r=0.26), BMI (r=0.21), BMC (r=‐0.21), BMD (r=‐0.27), DEXA body fat (r=0.28), and BIA body fat (r=0.23). However, HOMA did not significantly correlate to any question on the CI or symptoms during the OGTT. Results indicate that HOMA is positively correlated to OGTT glucose values, fasting insulin, the G/I ratio, waist circumference, BMI, and %BF and negatively correlated with height, BMC, and BMD but not related to CI questionnaire items or CI symptoms during an OGTT.Grant Funding Source : Curves International, Inc. (Waco, TX)