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The effect of food restriction on the expression of some placental proteins (LB24)
Author(s) -
Harrath Abdel Halim,
Mansour Lamjed,
Al Omar Sulimen,
Alwasel Saleh
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.lb24
Subject(s) - placenta , pregnancy , fetus , biology , disease , immunohistochemistry , tumor necrosis factor alpha , receptor , physiology , endocrinology , medicine , immunology , genetics
Fast food and ready meals may be an important determinant in the significant increases of numerous diseases, such as reproductive disorders, because these foods are low in macro and micronutrients. In this study, we aimed to investigate whether food restriction in pregnant mothers affects placental structure and function. The rat represents an excellent organism for studying human disease and the main source for testing new drugs and to increasing knowledge of the pathobiology of human disease. The placentas from pregnant females under food restriction and controls were removed on the day 6, 14 and 20 of pregnancy. A panel of Sulimen Y. Al Omar1differentially expressed proteins, specifically tumor necrosis factor (TNF) signaling, TNF receptor 1 (TNFR1) and transforming growth factor‐β (TGF‐β) have been subjected to immunohistochemistry and molecular analysis. Our observations suggest that the expressions of some of these proteins were affected by the food restriction, and thus placenta is affected by the lack of nutrition during pregnancy. We conclude that these differentially expressed proteins are an effective target for measuring placental defects and related risks to the fetus development. Results from a rat model may be extrapolated to other species including humans. Grant Funding Source : Supported by Deanship of Scientific Research at king Saud University