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The effects of histone glutathionylation on chromatin structure (942.5)
Author(s) -
Blackshire Bradley
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.942.5
Subject(s) - histone , histone modifying enzymes , chromatin , histone code , chromatin remodeling , euchromatin , histone methylation , histone methyltransferase , microbiology and biotechnology , heterochromatin , histone h2a , transcription coregulator , biology , chemistry , genetics , nucleosome , dna , dna methylation , gene , gene expression
The Effects of Histone Glutathionylation on Chromatin Structure DNA transcription is dependent on interactions between DNA and associated histone proteins. Modifications to histones have the potential to influence DNA transcription by promoting euchromatin structure, such as in the acetylation of histones, or promoting heterochromatin structure, such as in the methylation of histones. Recent work has increased our understanding of the consequences of histone modifications. In particular, a recent study demonstrated that cells exposed to nitrosative stress show an increase in histone glutathionylation, a redox sensitive modification. The current project focuses on the ramifications of glutathionylation of histones on chromatin structure and its potential to regulate gene transcription. We show that glutathionylation promotes heterochromatin structure, which may lead to a decrease in gene transcription. These results have broader significance as chromatin remodeling may play a role in aging and neurodegenerative diseases. Grant Funding Source : STEM Title V