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Effectiveness of diode laser 904nm in the regeneration of bone defects in diabetic rats (922.17)
Author(s) -
Silva Jairo,
Fazan Valéria Paula,
Pardini Luís,
Thomazini José
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.922.17
Subject(s) - medicine , bone healing , diabetes mellitus , streptozotocin , regeneration (biology) , laser , low level laser therapy , endocrinology , surgery , laser therapy , biology , physics , optics , microbiology and biotechnology
The acceleration of bone formation in the repair of large bone defects is a major challenge in health science. Diabetes Mellitus is a chronic metabolic syndrome that causes decreased blood flow and consequently interferes negatively on the consolidation time of bone defects. Therapy with low intensity laser has shown efficiency in cellular regeneration and can influence immune and inflammatory responses that play an important role on bone tissue the regeneration. This study aims to evaluate the efficacy of 904nm laser diode in the regeneration of bone tissue to repair a bone defect in diabetic rats. Forty male Wistar rats were divided into 4 groups: Group 1, control, not diabetic and without laser treatment; Group 2, diabetic animals, induced by a single venous injection of streptozotocin (STZ) (40mg/Kg) without laser treatment; Group 3, diabetic animals treated with laser dose 60w 4J/cm for 17s every other day, for 14 days; Group 4, diabetic animals treated with laser dose 120w 4J/cm for 17s every other day, for 14 days. Bone defect was induced with a 2 mm drill on the left tibia and different groups were evaluated by X‐ray and bone densitometry. Our results show that the laser diode 904nm is enhancing bone repair in diabetic rats. Further histopathological evaluations will confirm these findings. Grant Funding Source : FAPESP, CNPq and FAEPA