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CAVE ő a proposed ontogeny ontology (917.1)
Author(s) -
Cork R.
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.917.1
Subject(s) - ontology , construct (python library) , context (archaeology) , computer science , evolutionary developmental biology , ontogeny , biology , comparative anatomy , variety (cybernetics) , evolutionary biology , anatomy , artificial intelligence , paleontology , philosophy , genetics , epistemology , programming language
The Virtual Human Embryo (VHE, virtualhumanembryo.lsuhsc.edu ) is a digital atlas that has become a canonical reference for the microscopic anatomy of human embryos. We propose to extend this concept to a variety of other species, with a project called CAVE (Comparative Atlas of Vertebrate Embryology). CAVE will include model species used for developmental biology research, as well as evolutionary significant species that can provide insights into the field of evolutionary developmental biology (evo‐devo). To allow researchers to search and compare these databases we are also proposing to construct a developmental anatomy ontology. This ontology will not only provide a space‐filling description of the anatomy at different time points during development but will also put the developmental anatomy into a temporal context that will enable the processes of development to be described. Thus, anatomical structures will be related to each other using relationships such as is_a and part_of , terms such as first_appears_at and disappears_at will describe the anatomical structures on a temporal axis, and terms such as develops_from and develops_into will be used to describe temporal relationships between anatomical structures. The ontology will be annotated with section images from the VHE and CAVE databases so that specific anatomical structures can be quickly located in the databases and compared across species.