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Ontogenic analysis of the PACAP receptor, PAC1R, in mouse major salivary glands (916.1)
Author(s) -
aka Naoko,
Nakamura Masanori
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.916.1
Subject(s) - saliva , anatomy , medicine , biology
The control of saliva secretion is mainly under the autonomic nervous control. Pituitary adenylate cyclase‐activating polypeptide (PACAP) is now recognized as the multi‐functional neuropeptide in various organs. Previous our study indicated the localization of PAC1R in adult mouse major salivary glands. In this study, we examined the ontogenic expression of PAC1R in mouse salivary glands. Salivary glands at 0, 3, 5, 7, 14 and 21 days postnatal male C57BL/6 mice were used for the immunohistochemical detection of PAC1R. In parotid gland, the acinus was not clearly formed and PAC1R was not detected until 14 days after birth. At 14 days, PAC1R was detected in the striated duct. In sublingual gland, Acinus and duct were formed at 0 days after birth. PAC1R was constantly expressed in the striated duct from 0 day postnatal stage. In the case of submandibular gland, granular duct was not clearly identified and PAC1R was localized in striated first detected in striated duct until 21 days after birth. After 21 days, PAC1R was clearly detected at pillar cells in granular duct. Some of cells in the duct showed intense immunoreactions of PAC1R. These results indicated that PAC1R was expressed in the striated duct of parotid and sublingual glands and that the localization of PAC1R was changed with the formation of granular duct. The precise study might be necessary to clarify the function of pillar cells by examining the shift of PAC1R‐positive cells in submandubular gland.