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Changes in diacron‐reactive oxygen metabolites and biological antioxidant potential in maternal serum during pregnancy (910.6)
Author(s) -
Kawashiro Yukiko,
Ishii Kuniko,
Hosoyamada Yasue,
Miyaso Hidenobu,
Matsuno Yoshiharu,
Kubonoya Kiyoshi,
Mori Chisato,
Hanazato Masamichi
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.910.6
Subject(s) - antioxidant , oxidative stress , gestation , pregnancy , medicine , reactive oxygen species , physiology , antioxidant capacity , gestational age , endocrinology , chemistry , biology , biochemistry , genetics
The objective of this research is to identify changes in serum oxidative stress and antioxidant levels during normal pregnancy using the diacron‐reactive oxygen metabolites (d‐ROMs) test and biological antioxidant potential (BAP) test. This cross‐sectional study enrolled 126 pregnant women who attended a maternity clinic in Japan. Healthy, non‐pregnant women of reproductive age were recruited as controls. Serum d‐ROMs and BAP were measured within 72 hours using a Free Radical Elective Evaluator. Subjects were divided into five groups: 8‐13 w (n=15), 14‐27 w (n=42), 28‐32 w (n=31), 36‐37 w (n=38), and control (n=7). The pregnant women’s average d‐ROMs and BAP levels were 499.4 ± 99.0 U.CARR and 1977.1 ± 179.3 μmol/l, respectively. The d‐ROMs level in 36‐37 w group increased significantly compared with the control, 8‐13 w and 14‐27 w groups (p=0.000, p=0.009, p=0.006). The BAP level in the 36‐37 w group decreased significantly compared with all other groups (p=0.000). These results suggest that oxidative stress increases and antioxidant power decreases throughout the gestational period, and that the pro‐oxidant antioxidant balance is disturbed most at the end of gestation. Grant Funding Source : KAKENHIGrants‐in‐Aid for Scientific Research)