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Resistance exercise improves the iron status without increasing the iron absorption in iron‐deficient rats (907.1)
Author(s) -
Fujii Takako,
Nakashima Ayumi,
Tanaka Chihiro,
Matsuo Tatsuhiro,
Okamura Koji
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.907.1
Subject(s) - hepcidin , transferrin saturation , chemistry , endocrinology , hemoglobin , iron status , medicine , serum iron , ferroportin , dmt1 , hematocrit , ferritin , transferrin , absorption (acoustics) , iron deficiency , transporter , biochemistry , anemia , serum ferritin , materials science , gene , composite material
We have previously reported that resistance exercise improved the iron status in iron‐deficient rats (Fujii 2011). The current study investigated the mechanisms underlying this exercise‐related effect. Male four‐week‐old rats were divided into a sedentary (S) or an exercise (E) group, and all rats were fed an iron‐deficient diet (12 mg iron/kg) for eight weeks. The rats in the E group performed climbing exercise (5 min x 6 sets/day, 3 days/week). The hematocrit and hemoglobin levels were significantly higher in the E group than in the S group. The plasma iron and transferrin saturation and total iron content in the body measured using the whole body homogenates of the rats tended to be higher in the E group. The mRNA expression of hepcidin tended to be higher in the E group, while the mRNA expression of duodenal cytochrome b, divalent metal transporter 1 and ferroportin 1 did not differ between the groups. The apparent absorption of iron was significantly lower in the E group than in the S group. Therefore, the resistance exercise‐induced improvement of the iron status does not appear to be due to an enhancement of iron absorption.