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Differential effects of endurance training and resistance training on doxorubicin‐induced skeletal muscle dysfunction (884.5)
Author(s) -
Hydock David,
Bredahl Eric,
Gibson Noah,
Quinn Colin,
Hayward Reid
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.884.5
Subject(s) - endurance training , skeletal muscle , medicine , resistance training , soleus muscle , doxorubicin , endocrinology , treadmill , muscle fibre , chemotherapy
This study examined the protective effects of prior endurance training or resistance training on acute doxorubicin (DOX)‐induced skeletal muscle dysfunction. Male Sprague‐Dawley rats were endurance trained (motorized treadmill), resistance trained (raised food/water), or sedentary (normal cage activity) for 10 weeks, and following the activity treatments, animals received DOX. Skeletal muscle function was assessed ex vivo analyzing the soleus and extensor digitorum longus (EDL) to represent type I and type II muscle, respectively. DOX treatment resulted in decreased maximal twitch force in both the soleus and EDL. Endurance training provided the greatest degree of protection in the soleus whereas resistance training provided the greatest degree of protection in the EDL. The results suggest that exercise‐induced protection against DOX myotoxicity may be dependent on exercise mode and fiber type. Grant Funding Source : David S. Hydock, PhD was supported by MRSG‐12‐179‐01‐PCSM from the American Cancer Society