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Systemic blood pressure predicts disease severity of idiopathic pulmonary arterial hypertension (884.13)
Author(s) -
Sun XingGuo
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.884.13
Subject(s) - medicine , cardiology , vascular resistance , pulmonary artery , cardiac catheterization , blood pressure , pulmonary hypertension , coronary artery disease
NYHA class and objective measurements obtained during cardiac catheterization (CATH) and incremental cardiopulmonary exercise testing (CPET) are all used to assess the severity of idiopathic pulmonary arterial hypertension (IPAH). Methods: We retrospectively analyzed the first visiting data from 86 IPAH patients without known systemic hypertension evaluated. After signed consent forms, CATH and CPET data were obtained without intervening changes in therapy. We correlated % predicted peak O 2 uptake (%pkVO 2 ) and NYHA class with systolic blood pressure at rest (SBPr) and peak exercise (SBPp) during CPET and the following resting CATH measures: mean right atrial pressure (mRAP), mean pulmonary artery pressure (mPAP), total pulmonary vascular resistance (TPVR), SV, and CO. Data are reported as mean±SD. Results: The mean age was 44±14 yr, NYHA class 2.8±0.6, %pkVO 2 48±14%, and SBPp was 160±28 mmHg. Correlations from highest to lowest for %pkVO 2 were: SBPp=0.51 (p<0.0001), SBPr=0.48 (p<0.0001), SV=0.36 (p<0.01), TPVR=‐0.34 (p<0.01), CO=0.27 (p<0.05), mPAP=‐0.26 (p<0.05), and mRAP=‐0.07 (p>0.05). Correlations for NYHA class were: SV=‐0.29 (p<0.05 and SBPp=‐0.25 (p<0.05) only. Conclusion : In IPAH patients, easily non‐invasive measured resting systemic systolic blood pressure during CATH and CPET correlate better with NYHA, and especially by %pkVO 2 , than more commonly‐employed invasive measures obtained during CATH. Grant Funding Source : Chinese National High Technology Research and Development Program (863 Program) Project2012AA021009