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17β‐Estradiol replacement to ovariectomized rats ameliorates depression‐like behavior (876.2)
Author(s) -
Lu Jiangqiang,
Xu Yongjun,
Sheng Hui,
Tang Zhiping,
Ni Xin
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.876.2
Subject(s) - ovariectomized rat , endocrinology , medicine , hippocampus , estrogen , antidepressant , proinflammatory cytokine , inflammation , depression (economics) , economics , macroeconomics
Administration of estrogens elicits antidepressant‐like effects in female rats. However, the mechanism of this effect remains largely unknown. Inflammation and indoleamine‐2,3‐dioxygenase (IDO) have been implicated to play pivotal roles in the depression‐like behavior. The objective of the present study was to investigate whether estrogen deficiency‐induced depression‐like behavior is associated with inflammation and IDO activation in brain. It has been found that ovariectomy induced depression‐like behaviors in rats, while 17β‐estradiol (E 2 ) treatment for 12‐week ameliorated depression‐like behaviors in ovariectomized (OVX) rats. Ovariectomy resulted in a decrease in 5‐HT and BDNF levels and an increase in levels of IDO, proinflammatory cytokines IFN‐γ and IL‐6, TLR‐4 and phosphorylated NF‐κB (p65 subunit) in hippocampus but not in prefrontal cortex. These effects could be restored by E 2 ‐replacement. Serum E 2 level was inversely correlated with the levels of IDO, IFN‐γ and IL‐6, while positively correlated with 5‐HT in hippocampus. Our results suggested that estrogen inhibit inflammation and activation of IDO and maintains 5‐HT and BDNF level in hippocampus, thereby ameliorating depression‐like behavior. Grant Funding Source : Natural Science Fundation of China No.31371197