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Metabolic monitoring by the carotid body (873.8)
Author(s) -
Shirahata Machiko,
Shin MiKyung,
Polotsky Vsevolod
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.873.8
Subject(s) - carotid body , endocrinology , medicine , basal (medicine) , hypoxia (environmental) , carbohydrate metabolism , denervation , chemistry , insulin , metabolism , leptin , glucose uptake , hypoxic ventilatory response , stimulation , respiratory system , obesity , organic chemistry , oxygen
The carotid body is a multimodal sensor. Recently, it has been debated whether the CB also senses glucose and is excited by low glucose. In spite of the conflicting data resulted from different preparations, in vivo data have consistently shown that the CB is likely to be involved in the glucose metabolism. For example, stimulation of the CB by NaCN increased systemic blood glucose (Alvarez‐Buylleet al.); carotid sinus denervation eliminated an increase in blood glucose which was induced by chronic intermittent hypoxia (Shin et al.). We found that after 6 hours fasting, blood glucose in young mice (