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IgE and H. pylori titers in severe asthmatic subjects versus controls: antigen hyperreactivity or etiology? (870.1)
Author(s) -
Varanasi Laalasa,
Lankala Shreya,
Quinn Tim,
Herndon Betty
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.870.1
Subject(s) - medicine , titer , immunology , asthma , immunoglobulin e , helicobacter pylori , atopy , population , pulmonology , antigen , antibody , environmental health
Nearly 25 million Americans are asthmatic, and several triggers have been implicated for producing symptoms. Gastroesophageal reflux (GER), often caused by H. pylori , is common and may trigger asthma exacerbations. The hyperreactivity to antigens in atopic asthma may have effects on H. pylori ‐associated GER. The rationale for this study was t o determine, in a population of asthmatics and controls, if the H. pylori serum titer is related to elevated IgE (atopy). Sera from 58 severe asthma subjects and 24 control sera were used for IgE and H. pylori specific ELISAs to test for titer based on a 450 nm read of 2.000 or greater (high) or a read below 0.25 (low). Asthmatic IgE samples were 44.83% high, 12.06% low while controls were 8.3% high and 16.7% low. Asthmatic sera H. pylori t iters, read on the same scoring system, showed 16.07% high and 26.7% low. Control sera had no H. pylori high values and 61.9% low. 77.8% of the asthmatic subjects with high serum H. pylori titers had high serum IgE titers also. Only 11.1% of the asthmatic subjects with low H. pylori titers also had low IgE. No steroid use data were available for either group. We conclude that, in this patient population diagnosed as severe asthmatics by our hospital pulmonology dept, H. pylori is significantly more prevalent than in controls, although total IgE in asthmatics appears higher than H. pylori ‐specific IgE. Grant Funding Source : Supported by Student Sarah Morrison grant to LV