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The effect of acute exercise on circulating serum retinol binding protein 4 in seniors with and without impaired glucose tolerance (863.4)
Author(s) -
Young Laura,
Marcus Robin,
LaStayo Paul,
Drummond Micah,
Graham Timothy,
Symons J. David
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.863.4
Subject(s) - impaired glucose tolerance , medicine , retinol binding protein 4 , endocrinology , adipokine , insulin resistance , insulin
Retinol binding protein 4 (RBP4) is an adipokine that contributes to insulin resistance and impaired glucose tolerance. There are no published reports concerning the influence of acute exercise on circulating RBP4. We sought to characterize this response in (1) healthy, normoglycemic males (CON; 23±4 y, BMI 22.3±9.4), (2) seniors with normal fasting glucose and glucose tolerance (S‐NGT; 70±5 y, BMI 24.2±6.5), and (3) seniors with impaired glucose tolerance (S‐IGT; 73±8 y, BMI 26.4±5.3; n=7 per group). Glucose tolerance was based on a 75 g oral glucose tolerance test wherein 2 h glucose values (mg/dL) were: 97±21 (CON), 106±24 (S‐NGT), and 159±13 (S‐IGT; p<0.05 vs. CON and S‐NGT). 48 h after determining VO 2 max (ml/kg/min) in CON (56±10, p<0.05 vs. S‐NGT and S‐IGT), S‐NGT (33±8), and S‐IGT (29±8) subjects, participants completed 20‐min of cycling at 85% VO 2 max. RBP4 was assessed (ELISA) in venous samples obtained before exercise and 50‐min and 24 h post exercise. Pre‐exercise RBP4 concentrations (ug/mL) were greater (p<0.05) in S‐IGT (76±23) vs. S‐NGT (61±7) or CON (44±7) subjects. Values obtained at 50‐min and 24 h post exercise showed further increases after exercise (p<0.05) in the S‐IGT (99±23 and 77±25, respectively) vs. both S‐NGT (56±7 and 39±9) and CON subjects (40±7 and 47±21). These data indicate that in senior subjects with IGT, circulating RBP4 is elevated before exercise, with persistent elevation in recovery (50‐min and 24 h) from exercise. Ongoing studies will determine whether skeletal muscle RBP4 regulates insulin‐glucose homeostasis.