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Telemetric monitoring of blood flow and pressure in a chronic lamb model (862.7)
Author(s) -
Fujji Yasuhiro,
Centola Luca,
Kinouchi Katsushi,
Zhu Liqun,
Pitsillides Koullis,
Ferrier William,
Talken Linda,
Nasirov Teimour,
Reinhartz Olaf,
Riemer R. Kirk
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.862.7
Subject(s) - medicine , cardiology , pulmonary artery , blood flow , blood pressure , continuous monitoring , aorta , doppler effect , biomedical engineering , engineering , operations management , physics , astronomy
The lamb is an excellent model for the study of cardiopulmonary dynamics in small children. Steady state measurements of cardiovascular parameters such as blood pressure and blood flow in undisturbed subjects are challenging to acquire but essential in the continuous monitoring of cardiopulmonary and systemic interactions. We have established a chronic lamb model that incorporates a telemetry system (Transonic EndoGear Inc, Davis CA) capable of measuring up to five variables in the same animal. This provides a new opportunity to record uninterrupted comprehensive cardiovascular performance over an extended period of time. This telemetry system uses a Doppler‐based flowmeter that allows measurements of flow velocity using endo‐, epi and peri‐vascular mounted flowprobes. Blood pressure is measured with endovascular 3F solid‐sate pressure catheters. With this system, we have applied perivascular Doppler flowprobes in the superior vena cava, endovascular flowprobes in the main pulmonary artery and epivascular flowprobes on the aorta as well as endovascular blood pressure catheters in the left internal mammary artery, main pulmonary artery, and right atrium. The EndoGear system enables the chronic invasive monitoring of critical cardiovascular variables in untethered and unrestrained lambs for extended periods, providing new insight about the time course of postnatal pulmonary vascular adaptation.