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Beta2‐adrenoreceptor blockade reduces early post‐trauma hyperglycemia and pulmonary injury in obese rats (859.1)
Author(s) -
Xiang Lusha,
Lu Silu,
Mittwede Peter,
Clemmer John,
Hester Robert
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.859.1
Subject(s) - medicine , insulin resistance , insulin , endocrinology , myeloperoxidase , hypoglycemia , blockade , anesthesia , inflammation , receptor
Early hyperglycemia following severe trauma is correlated with increased complications. Insulin is commonly used for glucose control but accompanied by a risk of hypoglycemia. Obese patients exhibit insulin resistance and increased post‐trauma complications, including acute lung injury (ALI). Thus, early glucose control in obese trauma patients is important but challenging. We examined an alternative method to decrease the early post‐trauma hyperglycemia and ALI in obese Zucker rats (OZ) via the suppression of hepatic glucose release by treatment with the β2‐adrenoreceptor antagonist, ICI 118551 (ICI). Severe orthopedic trauma was induced to both hindlimbs followed by ICI treatment (iv.) for 6 hours, during which the fasting glucose was monitored. One day after trauma, plasma IL‐6 levels, lung neutrophil counts, myeloperoxidase (MPO) activity, and wet/dry weight ratio were measured. Following trauma, as compared to lean rats, OZ exhibited greater increases in glucose, IL‐6, lung neutrophil accumulation and MPO activity, along with a development of lung edema. ICI treatment had no effect on post‐trauma blood pressure or heart rate but decreased the post‐trauma hyperglycemia (Figure), lung neutrophil retention, MPO activity, and wet/dry weight ratio in OZ. These results suggest that β2‐adrenoreceptor blockade effectively reduces the early hyperglycemia and pulmonary injury in OZ after severe trauma.Grant Funding Source : AHA‐12SDG12050525, NIH HL‐51971, AHA‐12POST12060126, and HL‐89581