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Copeptin and norepinephrine during graded hypovolemic stress in women prone to vasovagal syncope (858.6)
Author(s) -
Lindenberger Marcus,
Skoog Johan,
Alehagen Urban,
Länne Toste
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.858.6
Subject(s) - presyncope , vasovagal syncope , hypovolemia , medicine , copeptin , cardiology , syncope (phonology) , anesthesia , blood pressure , heart rate , vasopressin
Objective: Vasovagal syncope is the most common form of syncope in young individuals, with increased incidence in women. Despite being common, the aetiology is not elucidated. The aim was to study various biomarkers involved in blood pressure homeostasis in women prone to vasovagal syncope. Design and Methods: Graded lower body negative pressure (LBNP) to presyncope was used determine LBNP tolerance index (LTI) in 13 young women prone to vasovagal syncope (VVS) and 15 matched controls (C). Plasma levels of Norepinephrine (P‐NE), Copeptin, a surrogate marker of vasopressin (Cop) and midregion proadenomedullin (MR‐ProADM) was measured before and during graded LBNP. Results: LTI was lower in VVS (163±8) compared to controls (235±8) (P < 0.0001). VVS presented with increased levels of P‐NE at rest as well as LBNP of 30 mmHg, with similar levels at presyncope. P‐NE increase from rest to presyncope was smaller in VVS than in C (P = 0.01). Cop was greater in VVS during LBNP of 30 mmHg, but similar during presyncope. MR‐ProADM was unaffected by graded hypovolemia. Conclusions: Women prone to VVS present with increased levels of P‐NE and Cop during early LBNP, but with similar levels at presyncope, possibly as a result of greater hypovolemic stress at a given LBNP level. To elucidate its role in VVS, these data must be interpreted together with other data during hypovolemia.