Premium
Chronic effects of obstructive apnea on renal and lumbar sympathetic nerve activity in conscious rats (857.3)
Author(s) -
Miki Kenju,
Sukeguchi Chie,
Yoshimoto Misa
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.857.3
Subject(s) - medicine , anesthesia , apnea , obstructive sleep apnea , heart rate , blood pressure , basal (medicine) , lumbar , cardiology , surgery , insulin
This study investigated responses of renal (RSNA) and lumbar sympathetic nerve activity (LSNA) of rats to repeated obstructive apnea over 4 days. Wistar male rats were chronically instrumented for measurements of RSNA, LSNA, and oxygen saturation of the brain tissue, and a tracheal balloon for induction of apnea was implanted. At least 3 days after the surgery, the rats were subjected to obstructive apnea by inflating the tracheal balloon for 40 seconds. This process was repeated 6 times/hour for 5 hours/day over a 4‐day period. The basal level of RSNA increased gradually and significantly throughout the 4‐day experimental period. The magnitude of the LSNA increase was less than that of RSNA. The basal levels of arterial pressure and heart rate remained within the normal ranges throughout the experimental period. These data suggest that repeated obstructive apnea activates RSNA in a cumulative manner, which may in part explain the underlying mechanism for development of hypertension in sleep apnea syndrome. JSPS Grant.