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Pentadecapeptide BPC 157 given intraarticulary counteracts knee osteoarthritis in rats (844.11)
Author(s) -
Sikiric Predrag,
Krstonijevic Zoran,
Sever Marko,
Lojo Nermin,
Drmic Domagoj,
Zenko Sever Anita,
Baric Marko,
Starcevic Neven,
Buljan Matko,
Zoricic Ivan,
Rasic Zarko,
Seiwerth Sven
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.844.11
Subject(s) - medicine , medial collateral ligament , saline , osteoarthritis , cartilage , anterior cruciate ligament , tibia , knee joint , hindlimb , patella , surgery , anatomy , pathology , alternative medicine
Rat osteoarthritis (transected anterior cruciate and medial collateral ligament, medial meniscectomy) exhibited large cartilage destruction, still preserved bone (4 weeks), proximal tibia (cartilage and bone) totally destructed (8 weeks), and severely impaired knee function (4, 8 weeks), in controls (saline, intraarticulary, volume 0.2 mL, bi‐weekly till 2 weeks prior to sacrifice (at weeks 4, 8). This was counteracted with pentadecapeptide BPC 157 (10 µg/kg), respectively. In BPC 157 rats knee articular (tibial and femoral) surface similar to nonoperative animals at 4 weeks, only few cartilage lesions at 8 weeks, thus, cartilage and bone preservation confirmed by X ray examination. Functionally, all parameters analysed (walking, leg pressure force, knee mobility ( o )) were improved and rat's leg length maintained. Unlike general failure in controls, BPC 157 rats walked as non‐operated rats, exhibiting better leg pressure force: i.e., BPC 157 rats after 4 weeks 23+/‐0.2N (operated) and 24+/‐0.5N (non‐operated leg) vs. controls 14+/‐1.1 N (operated) and 22+/‐ 0.3 N (non‐operated leg). BPC 157 rats exhibited constantly improved knee mobility (82 +/‐ 2.4 o (BPC 157) vs. 15 +/‐2.5 o (controls, 8 weeks). Grant Funding Source : Supported by Grant 108‐1083570‐3635, Ministry of Science, Education and Sports, Croatia