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Emetic and defecatory action of the prostanoid EP receptor agonist, sulprostone, in ferrets (840.9)
Author(s) -
Kan Kelvin,
Lu Zhengbing,
Wai Man,
Wong Yuen,
Jones Robert,
Rudd John
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.840.9
Subject(s) - agonist , prostanoid , pharmacology , medicine , endocrinology , chemistry , receptor , anesthesia
Prostanoid EP receptor agonists are used extensively for gynecological purposes but may be associated with gastric disturbance. Endogenously produced prostaglandins may also be associated with gastric dysfunction. In the present studies, we investigate the mechanism of the EP1/3 receptor agonist, sulprostone (30 µg/kg, i.p.), to induce emesis and defecation in ferrets. Sulprostone induced tachygastria (dominant frequency increased from 9.7±0.1 to 11.8±0.6 cpm; P<0.05) and hypertension (mean arterial pressure increased from 117.9±4.1 to 165.9±7.3 mmHg; P<0.05). Promethazine (3 mg/kg) potentiated sulprostone‐induced emesis (P<0.05). The emetic response was not antagonized significantly by metoclopramide (0.3 and 3 mg/kg), ondansetron (0.1 and 1 mg/kg), or scopolamine (3 mg/kg). Only scopolamine reduced significantly the defecatory response (P<0.05). Bilateral abdominal vagotomy was ineffective to reduce sulprostone‐induced emesis and defection. Sulprostone (10 µg) administered into the fourth ventricle was emetic (P>0.05). These data suggests that mechanisms controlling sulprostone‐induced emesis and defecation are distinct.