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Effect of immune modulators on the activity of enzymes after experimental myocardial infarction (832.10)
Author(s) -
Sarapultsev Alexey,
Gette Irina,
Abidov Musa,
Sarapultsev Petr,
Chupakhin Oleg,
Danilova Irina
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.832.10
Subject(s) - myocardial infarction , immune system , angiogenesis , inflammation , enzyme , medicine , antioxidant , infarction , cardiology , pharmacology , endocrinology , chemistry , immunology , biochemistry
It was revealed (patent RUS 2437165 from 13.04.2010) that application of immune modulators fosters reducing the severity of inflammation reaction, faster cicatrization, provokes angiogenesis. As tissue regeneration depends on energy supply of the cell, the goal of the research was studying the effect of immune modulators on the activity of enzymes involved in energy exchange in the damaged myocardium. The experiment was conducted with 65 male rats of the Wistar line. The immune modulators used were derivatives of 1,3,4‐thiadiazine (L‐17) and 3‐aminophtalhydrazine (AMP), exerting antioxidant effect as well. Modeling myocardial infarction was verified by morphological research methods and increasing activity of organo‐specific myocardium enzymes in the blood plasma. With experimental myocardial infarction, the myocardium tissue showed CPK activation and decreasing activity of LDH1,2 isoenzymes. Introduction of AMP facilitated faster cardiac enzymes normalization in the blood plasma of the animals than introduction of L‐17. Nevertheless, both compounds prevented decreasing activity of LDH1,2 induced by myocardial infarction modeling in the myocardium at early stages (1 day), without decreasing CPK activity at all stages of the experiment. Grant Funding Source : Supported by grant 12‐Ц‐41059