Premium
Anti‐inflammatory activities of licorice‐derived prenylflavonoids (830.30)
Author(s) -
Kang Hye Ryung,
Seo Ji Yeon,
Kim Seong Soon,
Kim Bo Ram,
Zakharova Alexandra,
Woo Ji Eun,
Kim Mi Hye,
Han Mi Kyung,
Kim JongSang
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.830.30
Subject(s) - glycyrrhiza uralensis , glycyrrhiza , anti inflammatory , chemistry , nitric oxide , nitric oxide synthase , traditional medicine , pharmacology , medicine , organic chemistry , pathology , alternative medicine
Glycyrrhiza uralensis (licorice) is a widely used oriental herbal medicine from which dehydroglyasperin C (DGC), dehydroglyasperin D (DGD), and isoangustone A (IsoA) are derived. Our previous study demonstrated that these three compounds isolated from licorice had the strongest antioxidant activities in vitro system. The objective of current study is to investigate which compound isolated from licorice has the highest anti‐inflammatory activity. The production of nitric oxide (NO) and inflammatory cytokines were determined for the media of murine macrophage RAW264.7 cells cultured in the presence of lipopolysaccharide (LPS). The effect of prenylflavonoids on the expression of LPS‐induced inducible nitric oxide synthase (iNOS), cyclo‐oxygenase‐2 (COX‐2), and phosphorylation of nuclear factor (NF)‐kappa B p65 were assessed by Western blotting. In addition, we confirmed that the nuclear localization of NF‐κB was blocked by prenylflavonoids as assessed by immunocytochemistry. Thus, prenylflavonoids merit further study to evaluate their practical usefulness as anti‐inflammatory agents and/or functional food ingredients. Grant Funding Source : Supported by NRF‐2010‐0027204 and 2011‐0009782 and IPET (High Value‐added Food TechnologyDevelopment Program, 2012, 112066‐3), S. Korea