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Taurine may affect redox homeostasis via regulation of thioredoxin interacting protein in endothelial cells (830.29)
Author(s) -
Vincent Andrew,
Scheers Nathalie,
Gabrielsson Britt,
Sandberg AnnSofie
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.830.29
Subject(s) - txnip , taurine , thioredoxin interacting protein , endothelial dysfunction , homeostasis , microbiology and biotechnology , chemistry , apoptosis , western blot , biochemistry , thioredoxin , biology , endocrinology , oxidative stress , amino acid , gene
Taurine, a bioactive compound abundant in herring, has been shown to be active against endothelial dysfunction, through the alleviation of high‐glucose induced apoptosis and increased proliferation in endothelial cells. The nutrient‐sensitive inhibitor of anti‐oxidant defence, TXNIP, has been shown to be up‐regulated during endothelial dysfunction. Through ELISA and western blot analyses we have found that TXNIP levels are affected by taurine treatment in endothelial cells. The results indicate that dietary taurine may be important for maintaining redox homeostasis of endothelial cells. Grant Funding Source : Supported by The Swedish Council for Environment, Agricultural Sciences and Spatial Planning