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Almond supplementation without dietary advice significantly reduces C‐reactive protein in subjects with poorly‐controlled type 2 diabetes (830.24)
Author(s) -
Sweazea Karen,
Johnston Carol,
Ricklefs Kristin,
Petersen Katherine,
Alanbagy Samer
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.830.24
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , biomarker , randomized controlled trial , stroke (engine) , nutrient , physiology , endocrinology , biology , mechanical engineering , ecology , biochemistry , engineering
The national cost of diabetes exceeds $174 billion annually in the United States. Heart disease and stroke are the primary causes of morbidity and mortality among people with type 2 diabetes (T2D). The objective of this 12‐week randomized, parallel‐arm controlled study was to determine if almond supplementation (1.5 oz/d) to a routine diet would improve diabetic and cardiovascular risk markers in subjects with T2D who are not currently taking insulin ( n =11) compared to matched controls with T2D ( n =10). Inclusion criteria stipulated that subjects have poorly‐controlled diabetes as characterized by HbA1c values between 6.5‐9.0%. While the results showed no significant difference in nutrient intake of subjects in the two groups, those in the almond‐treated group tended to consume fewer carbohydrates ( p =0.073). There were no significant differences in plasma markers of glucose regulation or oxidative stress between subjects in the two groups, whereas the inflammatory biomarker C‐reactive protein (CRP) was significantly reduced in subjects who consumed almonds (‐1.2% vs. 4.33%, p =0.029). Therefore, daily almond consumption in the absence of other dietary or physical activity modifications is beneficial for reducing inflammation in subjects with poorly‐controlled T2D. Grant Funding Source : Supported by the Almond Board of California.