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Skin whitening effects of flower extracts with high antioxidant activities (830.20)
Author(s) -
Lee BogHieu,
Choi JooYeon,
Yu Miri,
Jeong Gi Hee
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.830.20
Subject(s) - tyrosinase , ascorbic acid , skin whitening , melanin , antioxidant , chemistry , viability assay , edible mushroom , japonica , mushroom , food science , biochemistry , enzyme , traditional medicine , botany , cell , biology , pharmacology , active ingredient , medicine
This study was aimed to investigate whitening effect of seven flower extracts with high electron donating ability (EDA). CCK‐8 assay revealed that the cell viability rate of all the flower extracts was significantly higher than that of control. Whitening effects of the flower extracts were measured by mushroom tyrosinase inhibition rate, cellular tyrosinase activity and cellular melanin contents in B16F1 melanoma cells. Rhododendron molle (Blume) G. Don extract reduced mushroom tyrosinase activity by 35.1% than the control and ascorbic acids. At 500 ppm, Aruncus dioicus var. kamtschaticus extract suppressed tyrosinase activity by 45.8%. In case of cellular melanin content, Euscaphis japonica extract was significantly lower than the control and the ascorbic acid. As for gene expression level of TRP‐1, TRP‐2, and tyrosinase, relative quantification value of the Euscaphis japonica extract showed inhibition of expression of three melanogenic enzymes. In conclusion, flower extracts had shown strong whitening effect. These findings suggest that flower extracts may can be further developed and potential skin‐whitening or anti‐melanogenesis preparation for cosmetics and therapeutic use. Grant Funding Source : supported by Basic Science Research Program through the Natiional Research Foundation of Korea(NRF)