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Additon of atorvastatin and lycopene produce hypolipidemic and morphological changes in liver of a NAFLD rat model (829.34)
Author(s) -
Piña Rosa,
RamosGómez Minerva,
García Olga,
Rosado Jorge
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.829.34
Subject(s) - atorvastatin , steatosis , medicine , endocrinology , fatty liver , lycopene , lipid profile , rat model , cholesterol , chemistry , food science , carotenoid , disease
The present study evaluated the effect of atorvastatin (AT) and/or lycopene (LYC) on fatty liver induced with a high‐fat and high‐cholesterol diet (HFHC). Eighty two male Sprague Dawley rats (200 ± 10g) were randomly assigned to 8 groups: normal 4‐weeks (N4), HFHC diet for 4 weeks (model), normal 8 weeks (N8), HFHC diet for 4 weeks followed by 4 weeks of standard diet (DC), HFHC diet for 4 weeks followed by 4 weeks of standard diet plus 50 mg/kg AT (DC+AT50), HFHC diet for 4 weeks followed by 4 weeks of standard diet plus 20 mg/kg LYC(DC+LYC20), HFHC diet for 4 weeks followed by 4 weeks of standard diet plus 50 mg/kg AT and 20 mg/kg LYC (DC + AT50 + LYC20) and HFHC diet for 4 weeks followed by 4 weeks of standard diet plus 20 mg/kg AT and LYC respectively (DC + AT20 + LYC20). Treatments were given daily by oral intubation. Blood samples and livers were taken for the determination of serum lipid profile and histopathological examination. The model group showed a significant elevation of serum TC, TG, HDL and LDL concentrations in comparison with the normal N4 group. Interestingly, DC group showed similar lipid profile than N8 group and we observed no further reduction by the AT and/or LYC treatments. The model group showed steatosis grade II in 25% and grade III in 75% of the livers. In all the treated groups steatosis decreased significantly. In conclusion, AT and LYC improved liver morphology thus suggesting that these treatments have additional benefits than just the change of diet. Grant Funding Source : Partially supported by CONACYT