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Effect of long‐term administration of arginyl‐fructose on hyperglycemia and HbA1c in db/db mice model (829.30)
Author(s) -
Choi HwangYong,
Kang BouHee,
HA KyoungSoo,
Lee Mee Sook,
Kim YoungCheul,
Kim YoungHo,
Jang HeaDong,
Kwon YoungIn
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.829.30
Subject(s) - acarbose , endocrinology , medicine , fructose , carbohydrate , diabetes mellitus , leptin , chemistry , body weight , obesity , food science
To test whether Arginyl‐fructose (AF) play a role in the blood glucose lowering in db/db mice model, db/db mice were randomly assigned to high‐carbohydrate diets (66.1% corn starch), in AF contents (4% in diet) for 6 weeks. Changes in body weight, blood glucose level, and food intake were measured daily for 42 days. Administration of AF resulted in a significant decrease of blood glucose level and body weight. The level of HbA1c relevant to seriousness of diabetes was also significantly decreased during 6 weeks. Administration of acarbose® (0.04% in diet), positive control, also significantly alleviated the level of blood glucose, HbA1c, andb body weight. These results indicate that AF Maillard reaction product may have anti‐diabetic effect by suppressing carbohydrate absorption in the gastrointestinal level