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Grapeseed polyphenol + ∂‐tocotrienol favorably alters lipid profile in C57BL/6J mice with diet‐ induced non‐alcoholic steatohepatitis (829.28)
Author(s) -
Mendez Melissa,
Vijayagopal Parakat,
Juma Shanil,
Prasad Chandan,
Imrhan Vicky
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.829.28
Subject(s) - steatohepatitis , fatty liver , medicine , vitamin e , nonalcoholic fatty liver disease , endocrinology , tocotrienol , chemistry , polyphenol , biochemistry , tocopherol , disease , antioxidant
Diets high in fat are associated with the development of obesity and liver pathologies such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Currently there are no safe drug therapies for NAFLD or NASH, therefore there is a need for alternative therapies. Studies have shown that grapeseed polyphenol (GSP) and ∂‐tocotrienol (∂‐T) may have benefits in reducing NASH‐like symptoms. In this study we have examined the effects of dietary GSP, ∂‐T, and their combination (GSP+ ∂‐T) in C57BL/6J mice fed a high calorie high fat diet for 20 weeks to induce NASH‐like symptoms. The control group was fed high fat diet throughout the study. Hepatic and serum total cholesterol TC), triglycerides (TG), and vitamin E concentrations along with serum free fatty acids (FFA) were assayed. Hepatic and serum TC were significantly lower (p<0.05) in GSP and GSP+ ∂‐T compared controls and ∂‐T groups whereas hepatic TG was lower (p<0.05) only in GSP+ ∂‐T group. Both hepatic and serum vitamin E levels were lower (p<0.05) in GSP+ ∂‐T compared to control and ∂‐T groups. Serum TG and FFA were similar among the groups. Dietary GSP supplementation alone and in combination with ∂‐T attenuates NASH‐like features in C57Bl/6J mice by reducing serum and hepatic lipids. Grant Funding Source : Supported by the Research Enhancement Program, Texas Woman’s University.