Premium
RETRACTED: Can consumption of anthocyanin‐rich tomatoes reduce the risk of cardiovascular disease? (Experimental Biology 2014 Abstract Number 829.18)
Author(s) -
Achterfeldt Sebastian,
Martin Cathie,
Kroon Paul
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.829.18
Subject(s) - anthocyanin , disease , food consumption , biology , medicine , food science , physiology , agricultural economics , economics
The following abstract which was published originally in 2014 as part of the Experimental Biology 2014 meeting has been voluntarily retracted by the authors, except Sebastian Achterfeldt: THE FOLLOWING ABSTRACT HAS BEEN RETRACTED Anthocyanins (ACN) are responsible for the red to dark purple colours in various fruits and vegetables. Epidemiological studies have shown an inverse relationship between consumption of ACN and risk of diseases, particularly cardiovascular diseases (CVD). Supplementation of animal diets with ACN‐rich foods and extracts has been shown to reduce atherosclerosis, improve vascular function and alter gene expression. However, although these studies have provided evidence that anthocyanin‐rich foods can protect against CVD, they do not prove that the anthocyanins are responsible. Therefore, we undertook a unique study using genetically modified anthocyanin‐rich purple tomatoes as the treatment and anthocyanin‐free red tomatoes as the control in a dietary intervention study.ApoE ‐/‐ mice (n=20 per group) were fed different doses of purple tomatoes (0, 2.5, 5 or 10% w/w chow) with all groups receiving 10% total tomato. After 17 weeks of intervention, a number of markers of atherosclerosis, inflammation and gene expression were quantified. The data indicate that the anthocyanin‐supplemented diets caused significant reductions in the size of atherosclerotic lesions in the aortic arch, with reductions of up to approximately 40% compared to control for the group fed the highest dose of ACN‐rich tomatoes.These data show that consumption of anthocyanins within a complex plant food matrix causes reductions in the size of atherosclerotic plaques in a mouse model of human atherosclerosis. These findings support the notion that increasing anthocyanin consumption can reduce CVD risk. Grant Funding Source: Supported by EU FP7 (ATHENA‐245121) and BBSRC (UK). THE PRECEDING ABSTRACT HAS BEEN RETRACTED This was published in The FASEB Journal as an abstract only and there is no corresponding full article in the journal.