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B vitamins reduce body weight gain and increase metabolism related enzyme activities in rats (828.11)
Author(s) -
Aiguo Ma,
Zheng Ying,
Wang Qiuzhen,
Li Yong,
Liang Hui,
Han Xiuxia,
Schouten Evert,
Wu Da Yong
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.828.11
Subject(s) - transketolase , medicine , riboflavin , thiamine , endocrinology , weight gain , niacin , chemistry , vitamin , enzyme , metabolism , triglyceride , b vitamins , body weight , cholesterol , biochemistry , biology
B vitamins as enzyme cofactors play an important role in energy metabolism. The aim of this study was to determine whether B vitamins can affect body weight (BW) and activity of energy metabolism‐related enzymes in an animal model. Fifty Wistar rats were randomly divided to 3 groups and were fed a diet containing 10% fat (LF), a diet containing 45% fat (HF), or a HF diet supplemented with B vitamins (100 mg/kg BW for both thiamine and riboflavin, 250 mg/kg niacin) (HF+B). After rats were fed for 12 weeks, HF group had significantly larger weight gain than LF group (285.2±14.8 g versus 159.1±53.0 g, P <0.05), while HF+B group had a weight gain (154.5±58.4 g) not significantly different from that in LF group. In addition, compared to HF group, HF+B group had significantly lower levels of plasma total cholesterol (1.19±0.18 mM versus 1.59±0.30 mM), and triglyceride (0.76±0.34 mM versus 1.55±0.40 mM). Activity of transketolase, glutathione reductase, and Na + /K + adenosine triphosphatase was higher in HF+B group than that in HF group. In conclusion, B vitamin supplementation reduces HF‐induced weigh gain and increase in blood lipids, which may be associated with enhanced activity of the energy metabolism‐related enzymes. Grant Funding Source : NSFC‐81172662