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Anti‐inflammatory effects of JUVO (American style Saengshik) on high fat diet and dextran sulfate sodium‐induced colitis in C57BL/6J mice (824.8)
Author(s) -
Park KunYoung,
Song JiaLe,
Shin Sung Ho,
Park Myoung Gyu,
Hwang Sung Joo
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.824.8
Subject(s) - ulcerative colitis , colitis , h&e stain , azoxymethane , tumor necrosis factor alpha , medicine , proinflammatory cytokine , edema , inflammation , cytokine , inflammatory bowel disease , endocrinology , chemistry , gastroenterology , immunohistochemistry , colorectal cancer , cancer , disease
The aim of this study was to investigate the anti‐inflammatory effect of JUVO (J; an American style saengshik) on high fat diet(HFD, 45%) and dextran sulfate sodium (DSS, 2% wt/wt) induced ulcerative colitis (UC) in C57BL/6J mice. Saengshik (S) was used as a positive control. Body weight changes, colon length and ratio of colon length/weight were used to evaluate the preventive effects of JUVO in the colitis mice. Histological changes were observed by hematoxylin and eosin (H&E) staining. JUVO significantly suppressed HFD/DSS‐induced body weight losses and shortening of colon length, and decreased the ratio of colon length/weight. Histological observation suggested that JUVO suppressed edema, mucosal damage, and the loss of crypts induced by DSS. In addition, JUVO also decreased the serum and mRNA levels in the colon tissues of pro‐inflammatory cytokines including tumor necrosis factor‐α (TNF‐α), interleukin(IL)‐1β, IL‐6 and IL‐12. These results suggest that JUVO have an anti‐inflammatory effect on HFD/DSS‐induced ulcerative colitis in the mice, which through reduced pro‐inflammatory cytokine levels in serum and the colon tissue of the mice.