Effects of high and normocaloric diets on serum and thymus fatty acid profile: study on experimental model (821.3)

Objetive: To study the impact of high and normocaloric diets on serum and thymus´ fatty acid profile in growing rats. Weaning Wistar rats were fed during 10 days with 40% and 15% Kcal dietary fat provided by olive oil (groups O40; O15) high oleic oil (groups HO40; HO15) complete in all nutrients. Control group(C) received normocaloric diet. ω6/ω3 diets ratio: O=49,6 HO=86; C=9; Serum and thymus´ fatty acid profiles were determined by gas chromatography. Results (area% ±SD) ANOVA‐DUNNETT test was perform (*p<0.01):SERUM O40 HO40 O15 HO15 C Oleic 22.0±5.1 * 33.0±4.8 * 19,40±3,4* 26,88±3,1 * 10,6 ±2,0 Linoleic 11.8±2.8 * 8.9±1.0 * 12,44±1,8 * 7,89±1.4 * 19.0±3,5 Linolenic 0.5±0.2* 0.3±0.1* 0.34±0,06* 0.22±0.03* 1.2±0.3 THYMUSOleic 25,4±6,7 * 39.1±10,9 * 21,5±5,9 23,7±6,4 18,2 ±3,2 Linoleic 7,2±0,7 * 4,4±0,6 * 5,9±0,6 * 3,1±0,9 * 9,5±0,7 Linolenic 0.3±0.09* 0.2±0.03* 0.3±0.02* 0.2±0.06* 0,6±0,1All experimental groups showed higher serum oleic and lower Linoleic and Linolenic acid levels compared with C. On thymus only 40% groups showed higher serum oleic acid, but all groups had lower Linoleic and Linolenic acids than C. Serum fatty acid levels changed in response to variations in fat%, ω6/ω3 diets ratio and the sources of dietary lipids. These facts would exacerbate the route of the ω9 family and decreases essential fatty acids. Grant Funding Source : Supported by UBACyT:20020120200068