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Meta‐analysis of genome‐wide association studies for circulating phylloquinone (818.9)
Author(s) -
Dashti Hassan,
Shea M,
Smith Caren,
Tanaka Toshiko,
Nalls Mike,
Kritchevsky Stephen,
Liu Yongmei,
Ordovás José,
Booth Sarah
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.818.9
Subject(s) - genome wide association study , genetic association , biology , genetics , candidate gene , gene , meta analysis , single nucleotide polymorphism , medicine , genotype
Phylloquinone (PK) is the primary dietary and circulating form of vitamin K. Low circulating PK has been associated with abnormal calcification of soft tissue. Because few studies have assessed the genetic component influencing circulating PK, we sought to identify common genetic variants associated with circulating PK concentrations by conducting a genome‐wide association (GWA) meta‐analysis of circulating PK in two populations of European descent from the Cohorts of Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Results from adjusted cohort‐specific GWA analyses were meta‐analyzed with inverse variance weights. No genome‐wide significant associations were observed in the meta‐analysis (n = 2,138). We found nominal associations (P<1×10−6) on five independent loci. These results suggest that the APOA1C3/A4/A5 gene cluster, involved in triglyceride transport, CYP4F2, involved in vitamin metabolism, COL22A1, a collagen gene, CTNAA2, a catenin gene, and CDO1, a cysteine dioxygenase gene, are candidate genes that may be associated with serum PK. Given the multiple determinants of circulating PK and small sample size of the current study, further investigation with a larger sample is warranted.