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VDRG polymorphisms interact with calcium plus vitamin D supplementation during pregnancy to affect bone mass of lactating adolescent mothers (818.10)
Author(s) -
Normando Paula,
Diogenes Maria Eduarda,
Cabello Giselda,
Cabello Pedro,
Donangelo Carmen,
Bezerra Flávia
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.818.10
Subject(s) - medicine , endocrinology , vitamin d and neurology , bone mineral , femoral neck , pregnancy , genotype , calcitriol receptor , calcium , vitamin , lactation , bone density , osteoporosis , biology , genetics , gene
We investigated the influence of vitamin D receptor gene (VDRG) polymorphisms on bone mass of lactating adolescents (14‐19 y) supplemented (n=26) or not (n=21) with calcium and vitamin D3 (600 mg + 200IU/d) from 26 wk of gestation until parturition. Bone mineral content (BMC), area (BA) and density (BMD) of total body (TB), lumbar spine (LS, L1‐L4), total hip and femoral neck (FN) were assessed by DXA, at 20 wk postpartum. VDRG polymorphisms rs1544410 (G>A) and rs10735810 (T>C) were determined by RFLP. The effects of polymorphisms and their interaction with supplementation were assessed by ANCOVA after adjustment for significant covariates. rs1544410 (G>A) and supplementation interacted to affect TBBMC (P<0.05), TBBMD Z score (P=0.07) and FNBMC (P<0.05). Supplemented mothers with GA genotype had higher TBBMC (8.8%), TBBMD Z score (18.2%) and FNBMC (10%) than placebo with the same genotype (P<0.05). No isolated effects of polymorphisms nor significant interactions between rs10735810 (T>C) and supplementation were observed. Our results suggest that the effect of calcium plus vitamin D supplementation during pregnancy on bone mass of lactating adolescents can be modulated by VDRG polymorphisms. Lactating mothers with GA genotype seemed to be more responsive to supplementation in the tested conditions. Grant Funding Source : Supported by CNPq, FAPERJ