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Hypolipidemic potentials of mistletoe exudates in monosodium glutamate‐induced hyperlipidemia in rats (813.13)
Author(s) -
Ogunlabi Olugbenga,
Adegbesan Bukunola,
Ajani Emmanuel
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.813.13
Subject(s) - monosodium glutamate , glutamate receptor , acclimatization , distilled water , hyperlipidemia , sodium glutamate , chemistry , medicine , zoology , endocrinology , biology , botany , raw material , receptor , organic chemistry , chromatography , diabetes mellitus
Monosodium glutamate (MSG) intake could induce an increase in energy intake which could lead to obesity or alter the levels of carbohydrates, lipids and proteins in animals. It is an excitotoxin which may also damage the brain when taken orally without food. Monosodium glutamate (MSG), the sodium salt of amino acid glutamate, is a known food additive, popularly used as “flavour enhancer” all over the world, it is abundant in yeast extracts and other food ingredients without otherwise appearing on the label. Thus, it could be abused inadvertently. Thirty‐five adult female albino wistar rats weighing between 200‐250g were obtained and acclimatization under standard laboratory conditions for two week after which they were randomly assigned into five study groups of seven animals each. The groups were maintained on standard rat chow and water ad libitum in addition to the following oral treatment. Group I ‐ animals received a daily placebo of distilled water. Group II ‐ Rats were treated with 200mg/kg b.w MSG daily for 28 days. Group III ‐ Rats were treated with 200mg/kg b.w MSG and 200mg/kg b.w mistletoe aqueous extract daily for 28 days. Group IV ‐ Rats received 200mg/kg b.w MSG daily for 28 days after which the group was treated as in group III for an additional 28 days. Group V ‐ Rats received 200mg/kg b.w MSG daily for 28 days after which the animals were treated as in group I for an additional 28. At the end of 28 days, animals in groups I, II and III were sacrificed while animals in groups IV and V were sacrificed after 56 days. Blood samples were collected and used for lipid profile analysis. Results revealed a significant increase (p>0.05) in serum total cholesterol, LDL and TG for group II when compared with groups I, III and IV, while there was a significant decrease (p< 0.05) in serum HDL for group II compared with other groups This result suggests that mistletoe extract supplementation may ameliorate MSG‐induced hyperlipidemia in rats.