Premium
Short‐ and long‐term changes in plasma vitamin and mineral concentrations following laparoscopic Roux‐en‐Y gastric bypass surgery (812.2)
Author(s) -
UriuAdams Janet,
Miller Gary,
Fernandez Adolfo,
Gedestad Michael,
Ensunsa Jodi,
Carlson Charles,
Keen Carl
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.812.2
Subject(s) - medicine , body mass index , gastroenterology , ferritin , surgery , vitamin d and neurology , iron status , vitamin , iron deficiency , anemia
Over 340,000 bariatric surgeries are performed annually worldwide, many of them on young individuals. While successful weight loss can occur, it has been associated with a number of nutritional deficiencies. In this prospective study, blood was taken from 21 female patients (19 White, 2 Black; age = 44.5 ± 2 yrs; body mass index (BMI) = 54.8 ± 1.7 kg/m 2 ) at baseline and 3 wk, 3 mo., 6 mo. and 12 mo. after RYGB surgery to determine the extent to which select nutrient concentrations change over time. Average BMI at 12 mo. was 36.0 ± 1.4 kg/m 2 . At baseline, 47.7% were characterized by vitamin D (25OHD) <20 ng/ml and 33.3% had 25OHD between 20‐30 ng/ml. By 12 mo., these levels represented 18% and 38.1% of the subjects, respectively. Iron status was lowest at 3 wks post‐surgery as evidenced by low plasma iron and high transferrin receptor levels. Inflammation was evident (hsCRP >10 mg/ml) at baseline. The highest hsCRP level was observed at 3 wks post‐surgery and decreased over time. Consistent with an acute‐phase response, ferritin levels were highest at 3 wks post‐surgery. Plasma zinc levels were highest at 3 wks post‐surgery. None of the women were characterized with zinc deficiency (<0.5 µg/ml). Prevalence of low copper status (<0.8 µg/ml) at baseline was 14.3% and increased to 31.6% by 12 months. These data support the concept that short and long‐term changes in nutritional status are common after RYGB surgery.