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Moderate alcohol consumption and hemoglobin A1C in women with previous gestational diabetes (811.6)
Author(s) -
Ferranti Erin,
Dunbar Sandra,
McCullough Marjorie,
Ziegler Thomas,
Narayan K. M. Venkat,
Reilly Carolyn,
Foster Jennifer
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.811.6
Subject(s) - medicine , body mass index , gestational diabetes , diabetes mellitus , type 2 diabetes , pregnancy , obstetrics , cross sectional study , hemoglobin , gestation , endocrinology , pathology , biology , genetics
Objective: We examined alcohol consumption in relation to hemoglobin A1C levels in women within five years of a pregnancy affected by gestational diabetes (GDM). Methods: This study was a cross‐sectional design. Habitual alcohol consumption was assessed with the Block 2005 food frequency questionnaire. Elevated hemoglobin A1C levels were defined as 蠅 5.7% and measured with the Bayer A1C Now+ meter. Body mass index (BMI) was calculated from measured height and weight. Data analysis included descriptive, bivariate statistics, and multiple linear regression. Results: Participants (n = 74, 54% non‐white); mean age 35.6 (SD = 5.5) years and were 2.5 (SD = 1.6) years since their GDM delivery. Nearly half (47.3%) had an elevated A1C. Mean alcohol intake was 0.44 (SD = .64) servings/day. Greater consumption was associated with lower A1C (rho = ‐.45, p = <.0001). Alcohol intake was higher in those without diabetes risk (M = .59, SD = .66 servings per day) compared to those with diabetes risk (M = .27, SD = .58 servings/day; t = 2.2, p = .03). In multiple regression analysis, adjusted for age/race and BMI, alcohol intake was not associated with A1C (β = ‐.14, p = .21), but BMI was (β = .48, p = <.0001). Conclusions: Women within five years of a GDM pregnancy are at high risk for T2DM development. Although the unadjusted analysis revealed that alcohol had a protective effect on A1C, BMI was the only significant independent predictor of glycemia in this small sample. Clinical efforts focused on weight management should be a high priority to reduce T2DM risk. Grant Funding Source : Supported by the American Heart Association, National Institute for Nursing Research, NIH,