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Immune response influences in an adolescent cohort examined for the pathogenesis of mood disorders (811.26)
Author(s) -
Aldoori Ayat,
Algorta Guillermo,
Ziouzenkova Ouliana,
Gracious Barbara
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.811.26
Subject(s) - medicine , mood , immune system , endocrinology , vitamin d and neurology , inflammation , mood disorders , body mass index , monocyte , immunology , psychiatry , anxiety
We investigated immune response and oxidative stress in adolescent subjects with varying severities of mood disorders. To assess immune response we measured the profile of immunomodulatory vitamin D, cytokines monocyte chemotactic protein‐1 (MCP‐1) and interleukin‐6 (IL‐6), as well as their transcriptional regulator nuclear factor‐kappa B (NF‐kB) in patients’ serum. Although the markers of inflammation were not significantly different between groups, there appears to be an inverse trend (mean non‐mood 136.19±37.61 versus severe mood 110.76±43.77, p=0.20) between severity of mood disorders and NF‐kB activation. Similarly, MCP‐1 and IL‐6 levels tend to decrease with increasing severity of mood disorder. Obesity measured by BMI significantly correlates with serum IL‐6 levels (r=0.29, p=0.02). There was a significant inverse correlation between BMI of subjects and vitamin D (r=‐0.40, p=0.001) and a significant inverse correlation between vitamin D and IL‐6 (r=‐0.28, p=0.03). There was a significant correlation between vitamin D level and anti‐oxLDL (r=0.28, p=0.03) and a positive trend between vitamin D and MCP‐1 levels (r=0.23, p=0.07). Our findings suggest that lower vitamin D levels are associated with higher BMI in mood disorder patients. The elevated BMI is associated with higher adipose tissue mass producing IL‐6 which possibly leads to higher serum IL‐6 levels. This response appears to be counteracted by vitamin D. Groups affected by varying severity of mood disorders have no pronounced difference in immune response measured by several factors, although groups with the same diagnosis may yield a different a result. Grant Funding Source : Supported by NIMH