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Association of marijuana use with oxidative stress and antioxidant nutrients in HIV + adults on antiretroviral therapy (810.34)
Author(s) -
Vraney Joy,
Stewart Tiffanie,
Campa Adriana,
Greer Pedro,
Li Yinghui,
Martinez Sabrina,
Baum Marianna
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.810.34
Subject(s) - oxidative stress , antioxidant , population , medicine , carotenoid , glutathione , physiology , food science , biology , environmental health , biochemistry , enzyme
Objective : To assess the effect of marijuana (MJ) use on oxidative stress and antioxidant intake in 201 HIV+ adults with a high exposure to MJ. Methods : Plasma oxidized glutathione and 8‐oxo‐dG were collected. Intakes of Vitamins A, E and C, carotenoids, Selenium, and Zinc were assessed by 24‐hour recalls. Results: Mean age was 45.2±8.1 years and 27% used MJ. Users were significantly younger than non‐users (42 vs. 46 years, p<0.01). There were no significant differences between MJ users and non‐users in markers of oxidative stress, although the mean oxidative stress was well above the mean for the general population and the mean antioxidant intakes were all under the RDAs. Conclusions: In HIV+ adults, there were no differences in markers of oxidative stress and antioxidant intakes between MJ users and non‐users, probably due to the high levels of oxidative stress and low antioxidant intakes in this population, showing that this population may benefit from antioxidant supplementation. MJ use is still controversial, and our findings were limited by small sample size. More controlled research is needed to assess advantages and disadvantages of MJ use in this population with a high rate of exposure. Grant Funding Source : NIDA and NIAAA