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Insulin resistance and lipid profile in diabetic adults with depression (810.24)
Author(s) -
Kim Wookyoung,
Shin Dayeon,
Song SuJin,
Song Won O.
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.810.24
Subject(s) - depression (economics) , medicine , insulin resistance , diabetes mellitus , endocrinology , blood pressure , cholesterol , national health and nutrition examination survey , lipid profile , population , environmental health , economics , macroeconomics
The interaction between depression and diabetes mellitus (DM) is of considerable interest. A few studies focused on the effect of depression on self‐management in DM patients. This study aimed to investigate the relationship between depression and clinical biomarkers related to complications in DM. We analyzed the National Health and Nutrition Examination Survey data with sampling weights (2007‐2010). The prevalence of depression was higher in adults with DM than in healthy subjects (47.8% vs. 33.2%, p<0.0001) and in women than in men (56.0% vs. 37.2%, p<0.0001), and were older than those without depression (59.1±0.8 vs. 55.2±0.7, p=0.0014). Compared to the adults with DM without depression, those with DM and depression had higher mean BMI (33.7±0.8 vs. 32.8±0.5, p =0.0019); lower diastolic blood pressure (70.0±1.1 vs. 69.2±2.2, p=0.0196); higher total cholesterol (191.7±3.9 vs. 181.5±3.5, p=0.0010) and LDL‐cholesterol (102.9±2.7 vs. 98.5±4.2, p=0.0859), and lower HDL‐cholesterol (44.9±1.0 vs. 47.7±1.0, p=0.0130) after age and gender were controlled; and higher serum insulin levels (20.9±2.8 vs. 15.0±1.3, P=0.0031) and HOMA‐IR (8.3±1.3 vs. 6.4±0.8, P=0.0512) when adjusted for age, gender, and BMI. DM adults with depression show higher risks for comorbidity such as hypertension and cardiovascular diseases than in DM adults without depression.