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Bioavailability of enteric‐coated microencapsulated calcium during pregnancy: a randomized crossover trial in Bangladesh (804.4)
Author(s) -
Pezzack Brendon,
Zlotkin Stanley,
Abrams Steven,
Hawthorne Keli,
Al Mahmud Abdullah,
Baxter JoAnna,
Aimone Phillips Ashley,
Islam Munirul,
Dimitris Michelle,
Ahmed Tahmeed,
Roth Daniel
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.804.4
Subject(s) - bioavailability , enteric coating , crossover study , calcium , chemistry , absorption (acoustics) , calcium metabolism , medicine , nuclear chemistry , pharmacology , dosage form , chromatography , materials science , alternative medicine , pathology , placebo , composite material
Prenatal calcium (Ca) and iron (Fe) supplements are recommended in settings of low dietary Ca intake and high prevalence of anemia. However, concurrent Ca and Fe administration may inhibit Fe absorption. Therefore, we developed a multi‐micronutrient powder containing Fe (60 mg), folic acid (400 µg), and Ca (0.5, 1.0 or 1.5 g) in which calcium carbonate granules were microencapsulated with a pH‐sensitive enteric coating to delay intestinal release and limit Ca‐Fe interactions. To compare the fractional intestinal absorption (fAb) of Ca from enteric‐coated (EC) Ca granules versus uncoated (non‐EC) granules, we conducted a randomized crossover trial among pregnant women (n=49) in Dhaka. fAb was estimated by a dual stable isotope method ( 44 Ca‐labeled granules and intravenous 42 Ca), based on the relative recovery of 44 Ca vs 42 Ca in urine over 48 hours. Mean (±SD) fAb from EC Ca was significantly less than from non‐EC Ca (2.7±2.2 % vs. 16.5±10.0 %; p<0.0001) at all 3 Ca doses. In conclusion, the pH‐sensitive enteric coating substantially reduced Ca absorption. Therefore, in its current formulation this novel enteric‐coated Ca‐Fe supplement is not suitable for clinical use. Grant Funding Source : Supported by Saving Lives at Birth