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Retinol and tocopherol status in pulmonary tuberculosis patients in the country of Georgia (804.29)
Author(s) -
Jones Jennifer,
Frediani Jennifer,
Tukvadze Nestan,
Kipiani Maia,
Sanikidze Eka,
Hebbar Gautam,
Booth Sarah,
Blumberg Henry,
Tangpricha Vin,
Ziegler Thomas
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.804.29
Subject(s) - retinol , tocopherol , medicine , vitamin , vitamin e , gastroenterology , analysis of variance , physiology , endocrinology , antioxidant , biology , biochemistry
Objective: Evaluate serial plasma retinol and tocopherol levels in adults with new pulmonary tuberculosis (TB) in Tbilisi, Georgia. Methods: 129 subjects with pulmonary TB disease were enrolled in a randomized, controlled trial of high‐dose vitamin D3 (D3) + anti‐TB drugs. Plasma retinol, α‐tocopherol, and γ‐tocopherol were measured by HPLC (baseline, wks 8 and 16). Household contacts of TB subjects were baseline controls. Descriptive statistics (mean ± SD) and repeated measures ANOVA were used. Results: TB subjects exhibited significantly lower baseline plasma retinol (33.3 ± 11.7 vs. 58.8 ± 17.7 µg/dL; p < 0.001) and γ‐tocopherol (33.6 ± 15.6 vs. 40.8 ± 15.5 µg/dL; p = 0.02) levels vs. controls; α‐tocopherol levels were similar. D3 administration did not affect nutrient levels over time. Pooled data in all TB subjects revealed an increase in retinol levels over time (baseline to wk 16, +22%; p < 0.001). Levels of γ‐tocopherol rose at wk 8 (+11%; p < 0.001) but declined to baseline by wk 16. In contrast, α‐tocopherol fell by 9% at wk 16 vs. baseline (p < 0.01). Subjects with a BMI < 18.5 (n = 19), exhibited lower α‐tocopherol levels at wk 16 vs. baseline and wk 8 values (p = .003). Conclusions: Plasma retinol and tocopherol levels were lower in subjects with TB disease vs. uninfected household contacts. During anti‐TB treatment, plasma retinol increased and α‐tocopherol decreased, particularly in the more malnourished patients. Grant Funding Source : Supported by NIH K24 DK096574 and Emory Global Health Institute