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Gene expression alterations in patients with post‐traumatic stress disorder (776.6)
Author(s) -
Muhie seid,
Yang Ruoting,
Hammamieh Rasha,
Jett Marti
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.776.6
Subject(s) - transcriptome , endoplasmic reticulum , traumatic stress , microarray , gene , gene expression , microarray analysis techniques , medicine , biology , bioinformatics , microbiology and biotechnology , genetics , psychiatry
We profiled transcriptome changes in patients with post‐traumatic stress disorder (PTSD). Whole blood samples from 98 subjects (49 PTSD‐positives and 49 age, race and gender‐ matched controls) were assessed using microarray and real time polymerase chain reaction assays. About 1500 genes were differentially regulated in PTSD‐positive patients compared to the controls. Down‐regulated transcripts were involved in T‐cell immunity, cardiovascular activity, and synaptic transmissions. Suppressed pathways and functions were critical in maintaining one’s sense of well‐being, protective immunity, and cardiovascular health. Induced functions and pathways (significantly associated with up‐regulated transcripts) were largely related to traumatic stress responses such as endoplasmic reticulum stress, DNA repair, wound healing, and synaptic plasticity. Our data shows the pervasive negative impact of PTSD at the molecular level in regulation of key pathways and functions important to health. Grant Funding Source : US Army and Veteran's Affairs