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Determination of hydrolases, oxidases and synthases in hypertensive patients (771.1)
Author(s) -
Osman Mohamed Yousry,
Osman Hassan,
Moharem Dalia,
Elsaiedy Ahmed
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.771.1
Subject(s) - vasodilation , nitric oxide , enos , monoamine oxidase , chemistry , medicine , vasoconstriction , acetylcholine , essential hypertension , endocrinology , enzyme , nitric oxide synthase , blood pressure , biochemistry
Hypertension (HT) affects about 20 percent of the adult population placing a high burden on health care systems. Cholinestrase is responsible of the hydrolysis of the vasodilator acetylcholine. Monoamine oxidase (MAO) is responsible for degradation of the vasoconstrictor biogenic amines. Nitric oxide synthase (eNOS) is responsible for the production of the vasodilator nitric oxide (NO). The study aimed to find the relationship between these enzymes and essential hypertension in recently diagnosed patients. The results indicated a significant decrease in the activity of pseudo ChE in HT patients compared to control resulting in increase of ACh content and also indicated a significant decrease in plasma MAO‐A in HT patients saving the biogenic amines. Similarly; there is a significant decrease in the plasma nitrites + nitrates [NOx] of HT patients due to decrease in NOS activity. Eventually; it could be concluded that the investigated enzymes played a role in the regulation of essential HT. As the study showed; increase of 5‐hydroxytryptamine and adrenaline (due to decrease in MAO) that exceeded the decrease of pseudo ChE (increasing ACh content) and NOS (decreasing NO) resulting in vasoconstriction exceeding vasodilatation and the blood pressure consequently rises. Reversal of the previous mechanism could be helpful in treating essential HT. Grant Funding Source : Alexandria University