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Differential effect of high fat diet on tissue morphology and hormonal levels in male and female mice (765.1)
Author(s) -
Wong Nicole,
Donthireddy Laxminarasimha,
Babu Sathyapriya,
Adhikary Debasis,
Chakraborty Sanjoy,
Chakraborty Tandra
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.765.1
Subject(s) - medicine , endocrinology , hyperinsulinemia , adipose tissue , fatty liver , steatohepatitis , hyperplasia , pancreas , obesity , muscle hypertrophy , hormone , white adipose tissue , biology , disease , insulin resistance
The pathology of obesity produces many diseases. It has a far ranging negative effect on health including some type of cancers, non‐alcoholic fatty liver disease(NAFLD), diabetes and many other diseases that are related with obesity. This project was undertaken to observe the differences in the tissue morphology (liver, pancreas, adipose, heart, brain, kidney, spleen, ovaries and testes) in male and female mice when exposed to high fat diet for a period of 6 months. Within 3 months animals in VHFD showed signs of NAFLD and with longer treatment the liver showed deposition of lipid droplets in hepatocytes, which leads to non‐ alcoholic steatohepatitis (NASH) subsequently cirrhosis and hepatocellular carcinoma. Morphometric analyses of pancreas showed robust signs of inflammation, increase in pancreatic islets size and number in both obese male and female. Adipose tissue showed signs of hypertrophy than hyperplasia. The effect of high fat was more pronounced in males than females. obesity‐associated hyperleptinemia and hyperinsulinemia was observed in both males and female. Thus, these results suggests that high fat diet not only affects adiposity and hormonal imbalance but changes the cellularity and morphology of the tissue to such an extent that can lead to diseases that are fatal affecting men more than women.