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Vitamin D3, testosterone, epigenetics, and nocioception: an evolving concept of neurohomeostasis (727.3)
Author(s) -
Seigel Eric,
Thomas Marc,
Tulp Orien,
Einstein George
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.727.3
Subject(s) - epigenetics , testosterone (patch) , vitamin d and neurology , hormone , biology , bioinformatics , medicine , psychology , endocrinology , gene , genetics
To determine the effects of hormonal contributions to neurosignaling and clinical pain management, a study was undertaken to correlate the effects of plasma concentrations of vitamin D3, Testosterone, markers of epigenetics, and nocioception on outcomes via meta analysis of existing studies. Vitamin D3 and Testosterone have long been shown to be linked to molecular expression of numerous gene products, including calbindin, the homer‐1 gene, cytochrome P24, cytochrome P27, Bone Morphogenetic Proteins [BMPs] and others, all of which are proposed to have supporting molecular roles in neurophysiologic processes and in nocioception. The clinical descriptions that directly link Vitamin D3 or testosterone to pain are inconsistently linked, however, but the composite effects of relevant studies support an emerging concept of nocioceptive homeostasis and neuroplasticity that is in part epigenitcally mediated emerge, and thus include a likely contributory role for steroid hormones in the process of nocioception and certain clinical elements of pain management. Grant Funding Source : Institutional Resources